Great Assays for human iPSC-derived Neurons and Cardiomyocytes 2015

great assays workshop 2015

We thank our attendees, presenters and cooperation partners for the contribution to the overwhelming success of this workshop being held at the Axiogenesis headquarters in Cologne in November 25th – 27th 2015.

Feedback:

"Thanks for organizing this inspiring workshop." K. Fink (Merz)

"A big thank you for the well-planned workshop. It was very informative. For me it was a success since I gained insights into various devices and applications. Altogether, the workshop was well organized and Axiogenesis made us feel comfortable. One again thanks to the whole team." N. Glaser (Merck)

"Vielen Dank für den super Workshop." A. Ramme (TissUse)

"It was a great pleasure to attend the workshop, during which we grasped a lot of useful information that is reflected in our day to day research field. The workshop brought together the companies with the focus on novel techniques that may be directly applied in medical research. It has been as well comprehensive combination between lectures and demo sessions. The structure and the organization of the program allowed networking and information exchange. We would suggest that such workshops would launch the network as well towards the academia side." E. Liehn & M. Rusu (Institute for Molecular Cardiovascular Research (IMCAR) / University of Aachen) 


Showcasted live demonstrations:

Acea (xCELLigence)
Axion (Maestro)
Cytocentrics (Cytopatch2)
Essen Bioscience (IncuCyte)
Hamamatsu (FDSS 7000)
Multi Channel Systems (Multiwell-MEA-Systems)
Nanion (CardioExcyte96)
PerkinElmer (Operetta)
Seahorse (XF96)

Please download available presentations and posters by clicking on the according title within the agenda and contact Axiogenesis AG (This email address is being protected from spambots. You need JavaScript enabled to view it.) and our cooperation partners to receive information on specific assays.


Final Agenda:

Please note: download material will be complemented upon availability.

Wednesday, November 25

12:00 pm

Arrival at Axiogenesis Headquarter / LUNCH

01:15 pm

Axiogenesis AG / WELCOME

01:30 pm

Dr. Diana Toli (Sanofi Aventis Recherche)
“CHARACTERIZATION OF COR.4U® AS AN IN VITRO TOOL FOR MODELING CARDIOMYOPATHIES”

01:50 pm 

Prof. Dr. Philipp Sasse (University of Bonn)
“LIGHTLY FORCED: OPTOGENETIC CONTROL OF CARDIAC MUSCLE”

02:15 pm 

Oliver Keminer (Fraunhofer IME SP)
”HUMAN IPS CELL-DERIVED HIGH CONTENT SCREENING ASSAYS – CASE STUDIES FOR EARLY TOXICITY AND EFFICACY TESTING”

02:45 pm

Coffee break

03:30 pm

Live Demonstrations

INCUCYTE (ESSEN BIOSCIENCE)
MULTIWELL-MEA-SYSTEMS (MULTI CHANNEL SYSTEMS)
XF96 (SEAHORSE)

04:40 pm 

After Hour Kölsch

05:00 pm

Shuttle Bus to Hotels

07:00 pm

Dinner
GROUP DINNER AT “BRAUEREI ZUR MALZMÜHLE / HÖHNERHOF”

Thursday, November 26

08:45 am

Arrival at Axiogenesis Headquarter

09:05 am

Dr. Silke Schwengberg (Cells At Work / Acea Biosciences, Inc)
“MULTI-PARAMETRIC ANALYSIS OF CARDIOMYOCYTE EXCITATION-CONTRACTION COUPLING FOR PRE-CLINICAL CARDIAC SAFETY ASSESSMENT“

09:25 am

Dr. Thomas Meyer (Multi Channel Systems GmbH)
“MICORELECTRODE ARRAY BASED ELECTROPHYSIOLOGY FOR TOXICITY AND SAFETY TESTING ON IPS CELL-DERIVED CARDIOMYOCYTES AND NEURONS”

09:40 am

Dr. Sonja Stölzle-Feix (Nanion Technologies GmbH)
“CIPA TOOLS FOR CARDIAC SAFETY SCREENING: ANALYSIS OF COR.4U® CARDIOMYOCYTES IN HTS AUTOMATED PATCH CLAMP AND IMPEDANCE ASSAYS”

10:05 am

Dr. Olaf Scheel (Cytocentrics Bioscience GmbH)
“CYTOCENTERING PATCH CLAMP RECORDINGS OF IPSC-DERIVED NEURONAL CELLS AND COR.4U® CARDIOMYOCYTES”

10:25 am

Coffee Break

11:00 am

Dr. Julia Liebing (University of Dortmund, Leibniz Research Centre)
“USE OF SINGLE-CELL CALCIUM IMAGING TO IDENTIFY CELLULAR TARGET STRUCTURES OF NEUROTOXINS”

11:20 am

Anja Ramme (TissUse GmbH)
“TOWARDS THE DEVELOPMENT OF AN AUTOLOGOUS IPSC-DERIVED MULTI-ORGAN-CHIP”

11:40 am 

Dr. Benjamin Bader (Neuroproof GmbH)
“FUNCTIONAL AND PHENOTYPIC IN VITRO DISEASE MODELING USING HUMAN IPSC-DERIVED NEURONS GROWN ON MICRO ELECTRODE ARRAYS (MEAS)”

12:00 pm

Lunch Break

01:05 pm 

Heribert Bohlen (Axiogenesis AG)
KEYNOTE: “hIPSC-DERIVED CELLS IN DRUG DEVELOPMENT”

01:30 pm

Dr. Johannes Krupp (Ipsen AG)
“CHARACTERIZATION OF PERI.4UTM NEURONS FOR THE STUDY OF BOTULINUM NEUROTOXINS”

01:55 pm

Dr. Alexander Schreiner (PerkinElmer GmbH)
“CARDIOMYOCYTE HYPERTROPHY DETECTED BY HIGH CONTENT IMAGING AND ADVANCED TEXTURE ANALYSIS”

02:20 pm

Dr. Thierry Calmels (Bioprojet Biotech)
“CA2+ FLUX FOR PREDICTIVE TOXICITY OF GPCR LIGANDS IN HUMAN COR.4U® HUMAN CARDIOMYOCYTES”

02:45 pm

Coffee Break

03:30 pm

Live Demonstrations

CARDIOEXCYTE96 (NANION)
FDSS 7000 (HAMAMATSU)
CYTOPATCH 2 (CYTOCENTRICS)
MULTIWELL-MEA-SYSTEMS (MULTI CHANNEL SYSTEMS)
OPERETTA (PERKIN ELMER)

04:45 pm

Shuttle Bus to Hotels

 

Friday, November 27
08:45 am Arrival at Axiogenesis Headquarter 

09:05 am

Dr. Benjamin Wolters (Forschungszentrum Jülich GmbH)
“MODULATING THE TEMPORAL DELAY BETWEEN CALCIUM SIGNAL AND CELL CONTRACTION IN CARDIOMYOCYTES”

09:30 am

Dr. Ralf Kettenhofen (Axiogenesis AG)
“IDEAL CONDITIONS FOR A FLUORESCENT CA2+ TRANSIENT ASSAY ON THE FDSS USING COR.4U® CARDIAC MYOCYTES”

09:50 am

Dr. Christian Rimmbach (University of Rostock)
“GENERATION OF HIGHLY PURE PHYSIOLOGICALLY AND PHARMACOLOGICALLY FUNCTIONAL SINUS-NODAL-BODIES FROM PLURIPOTENT STEM CELLS”

10:10 am Coffee Break

10:40 am

Dr. Bernd Hoffmann (Beniag GmbH)
“LIPOSOMAL FUSION AS GENE TECHNOLOGY - FREE METHOD TO MODIFY IPS DERIVED CELLS AT FREE CHOICE”

11:00 am

Dr. Mark Bryant (Clyde Biosciences, LTD)
“OPTICAL MEASUREMENTS OF ELECTRICAL AND MECHANICAL FUNCTION OF COR.4U® CELLS USING THE CELLOPTIQ SYSTEM”

11:25 am

Dr. Susana Alcantara (Essen Bioscience, LTD)
“NOVEL WORKFLOW FOR PRECIOUS CELL ASSAYS USING INCUCYTE LIVE-CELL KINETIC IMAGING”

11:50 am

Live Demonstrations

FDSS 7000 (HAMAMATSU)
MAESTRO (AXION)
OPERETTA (PERKINELMER)
XCELLIGENCE CARDIO ECR (ACEA

13:00 pm

Departure

 


Posters:

1

"Evaluation of Drug Mediated Changes in Action Potentials & Calcium Transients Recorded from Adult Human Stem Cell-derived Cor.4U® Cardiomyocytes"

Axiogenesis

2

"Human iPSC-derived Cor.4U® Cardiomyocytes as a Predictive Tool for Different Comprehensive In Vitro Proarrhythmia Assay Endpoints: A Predictive In Vitro Model to Assess Drug-Induced Contractile and Metabolic Liabilities"

Axiogenesis

3

“Complementary Automated Patch Clamp, Extracellular Field Potential and Impedance Recordings of iPSCs: Drug and Safety Screening Tool Box for the Future”

Nanion
Technologies

4

“High Throughput Automated Patch Clamp of Ion Channels Important in Cardiac Safety and Drug Discovery“

Nanion
Technologies

5

“Keeping Up with the CiPA-Initiative: The Safety Screening Tool Box for the Future”

Nanion
Technologies

6

“Cor.4U® Human iPSC-derived Cardiomyocytes: A Suitable Cell Tool for Hypertrophy Efficacy and HTS Safety Screening”

Axiogenesis

7

“Quantifying Neurite Dynamics in Human iPSC-derived Neuronal Mono- and Co-Cultures Using Long Term Live Cell Imaging“

Essen
Bioscience

8

“High-Throughput Fluorescence Measurements of Ca2+ Transients in Human iPSC-derived Cardiomyocytes: Detection of Beating-Rate Dependence through Electric Field Stimulation“ Hamamatsu

9

“Measurements of Ca2+ Response in Human iPSC-derived Peripheral Neurons by Electric Field Stimulation in FDSS/μCELL“

Hamamatsu

10

“A New Approach to Analyze Cell Based Fluorescence Assay Data with Imaging Based Microplate Reader. A Proposal to Analyze the Data in a Well of Camera Based Microplate Readers in More Detail”

Hamamatsu

11

“Optogenetics: A Bright Future for Voltage Gated Ion Channels”

Hamamatsu

12

“The Multi-Organ-Chip Platform - A Cutting-Edge Approach to Toxicity Testing”

TissUse

13

“Human iPSC-derived Cardiac Myocyte-Fibroblast 3D Co-Cultures: A Predictive In Vitro Model to Assess Drug-Induced Contractile and Metabolic Liabilities”

Axiogenesis

14

“Automated Patch-Clamp Pharmacology Assays Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes”

Cytocentrics

15

“Extracellular Fieldpotential Recording from Pluripotent Stem Cell-derived Cardiomyocytes by Multiwell Microelectrode Arrays”

Multi Channel
Systems

16

“Functional and Phenotypic In Vitro Modeling of Parkinson’s Disease and Seizurogenic Effects Using Human iPSC-derived Neurons Grown on Micro Electrode Arrays (MEAs)”

Neuroproof

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