Axiogenesis AG has established itself over the last years as one of the world leaders in stem cell technology. The original work using mouse embryonic stem (ES) cells has now progressed to human induced pluripotent stem (iPS) cells, which provide more advantages in understanding human disease states and therapeutic intervention.
The primary focus has centred on developing heart cells that more closely represent cells under normal physiological conditions. These cells have huge potential in the development of innovative new therapies in several major ways: to test the toxic effects of drugs against the heart cells before a new drug is used into man, to identify new drug candidates by screening libraries against normal and cells expressing a certain disease stateto identify more accurately the biomarkers associated with disease to enhance patient selection, and improve the drug efficacy/safety profile of therapies use directly in potential cell-based therapies.
Source of Axiogenesis' revenues are products and services. CorAt®, a mouse-based cardiomyocyte (heart cell) was the first product. In 2013 the company has launched its human cardiomyocyte product Cor4U® in the market. Human Neuronal products have been launched in the autumn of 2014.
Beyond that there are strategies in place to meet most, if not all, of the potential uses listed above by broadening the offering in heart cells but also introducing other important cell lines such as nerve and liver. Business objectives will be achieved through a series of collaborations with pharma/biotech companies and in-house activities.
The existing business underpins Axiogenesis’ ability to compete effectively and to deliver break-even soon. Acknowledging the company's advancement in further potential stem cell products (i.e. human organ cells) Axiogenesis will be strengthening its drug discovery strategy.
The current market for C&S in the stem cell sector is still in its infancy and the company believes that there is significant market potential based on its experiences to date. The company expects the size of the market for stem cells to increase significantly over the next 5 years. Furthermore the human IPS segment is expected to demonstrate the most dramatic growth and also represent the biggest market segment in stem cells. This is exactly where Axiogenesis will be positioned.
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