Axiogenesis and MetaCell


Luxcel Biosciences, Axiogenesis and BMG LABTECH secure €2.5m European investment to develop and launch cell metabolism analysis platform: "MetaCell-TM"

Consortium to advance human iPSC-derived cell-based assay platform for metabolism analysis in preclinical drug discovery and development

Cork, Ireland, Cologne, Germany and Ortenberg, Germany: Three European technology SME’s, Luxcel Biosciences Ltd, Axiogenesis AG and BMG LABTECH GmbH, together with two internationally recognised research institutions, Oxford University and Imperial College London, have been awarded €2.5m funding from the European commission under the H2020 Fast Track to Innovation (FTI) pilot, to develop and launch a cell metabolism analysis platform that is predicted to be part of routine in vitro cell biology and drug development.

Axiogenesis MetaCell

The importance of advanced cell-based assays in preclinical drug discovery and development has risen significantly in recent years, with a major focus on cell metabolism and the use of models that better represent physiological and pathological conditions in cancer, cardiovascular and other diseases. This trend is not surprising considering 10-year timelines, steep costs associated with the development of new drugs (est. c. €2bn per drug) and the link between cell metabolism and drug failure.

Led by Luxcel Biosciences, the consortium will demonstrate a Gold Standard platform, comprising cell assays, disease models and services, together with high performance metabolism tests designed for use on laboratory standard instrumentation - the multi-mode microtiter plate reader.

For Axiogenesis, the advancement of this cell metabolism platform comprises an important strategic fit given that it nicely complements the  currently offered solutions which are mainly functional assays and services. Felix von Haniel, Commercial Director at Axiogenesis, said: "We are very excited to be part of this consortium. It greatly adds to our current portfolio, and broadens our application range in that it focuses not only on the safety / toxicity market, but in particular on drug discovery in the metabolic area. Also, the availability of ready-to-use kits makes iPSC-derived cells more easily accessible to a broader range of users, and is aligned with Axiogenesis’ philosophy to provide easy-to-implement iPSC-derived cells along with validated, physiologically relevant assays."

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“MetaCell-TM delivers a real alternative to expensive dedicated instrumentation, providing researchers with flexible, cost-effective access to tools measuring cell metabolism, bioenergetics and drug toxicity. We are delighted to partner with Axiogenesis and BMG LABTECH, who are recognised global leaders in iPSC-derived cell assays and advanced plate reader technology, to co-develop end-user solutions with direct impact on disease research and drug development” said Dr. Ian Hayes, Commercial & Operations Director, Luxcel Biosciences Ltd.

“We are excited to gain early access to this new platform and cell assays to complement our research. The system offers an easy to use format for studying metabolism that is not currently available”, said Professor Adrian L Harris, Oxford University Department of Oncology.

Please read HERE the original press release.


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