Astro.4U – Human iPS Cell-Derived Astrocytes

Astro.4U Human iPS Cell Derived Astrocytes

 

Product overview

Astro.4UTM are human iPSC- derived astrocytes supporting neuroscience research and drug discovery. Astrocytes are the most abundant cell type in the central nervous system (CNS) and, traditionally described, act as supporting elements for neurons. Recently, astrocytes have gained more recognition as essential players in information processing in the brain, as well as in various roles in neuronal homeostasis and synaptic plasticity. Additionally, increasing data support the critical role of astrocytes in disease progression, including neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Since current astrocyte models (i.e., primary or animal-derived) have many limitations with regard to translatability, reproducibility and availability, human iPSC-derived astrocytes provide a valuable tool to challenge the neuron-centric view of neurological disorders and study the role of astrocytes for drug discovery and disease modeling purposes.

Advantages of Astro.4UTM:

  • Differentiated low-proliferative human astrocytes with primary-like star-shaped morphology
  • Ready to use cells with long-term (>3 weeks) viability in culture
  • Established in co-culturing systems with Axiogenesis’ human neuronal cell products

 

Characterization

Astro.4U morphology

Phase contrast picture of Axiogenesis Astro.4U - human iPSC-derived astrocytes indicating the physiological star shaped morphologyAstro.4UTM have "star-shaped" morphology (after 7 days in culture)

 

Astro.4U are GFAP-positive

Astro4U GFAP immunofluorescence staining of Axiogenesis Astro.4U - human iPSC-derived astrocytesGFAP immunofluorescence staining of Astro.4UTM

 

Assays & Applications

Potential areas of use for Astro.4UTM include

  • General neuroscience research (e.g., CNS functionality, neurogenesis)
  • Astrocyte-mediated neurotoxicity 
  • Neuro-protection assays
  • Inflammation assays 
  • Disease modeling (e.g., neurodegenerative disease)
  • Tissue modeling 

  

Ordering information

Next day delivery is available for both European and US customers.

For sales inquiries and data requests, contact us at This email address is being protected from spambots. You need JavaScript enabled to view it.

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