Peer-reviewed Publications

Axiogenesis AG is committed to producing and publishing high-quality science to advance the field of stem cell research and drug development. See below for selected peer-reviewed publications.

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2016


Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing.

Johan U. Lind, Travis A. Busbee, Alexander D. Valentine, Francesco S. Pasqualini, Hongyan Yuan, Moran Yadid, Sung-Jin Park, Arda Kotikian, Alexander P. Nesmith, Patrick H. Campbell, Joost J. Vlassak, Jennifer A. Lewis and Kevin K. Parker; Nat Mater. 2016 Oct 24. doi: 10.1038/nmat4782.


Comprehensive Translational Assessment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias.

Blinova K, Stohlman J, Vicente J, Chan D, Johannesen L, Hortigon-Vinagre MP, Zamora V, Smith G, Crumb WJ, Pang L, Lyn-Cook B, Ross J, Brock M, Chvatal S, Millard D, Galeotti L, Stockbridge N, Strauss DG; Toxicol Sci. 2016 Oct 3. pii: kfw200.


The use of ratiometric fluorescence measurements of the voltage sensitive dye di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes.

Hortigon-Vinagre MP, Zamora V, Burton FL, Green J, Gintant GA, Smith GL; Toxicol Sci. 2016 Sep 11. pii: kfw171.


Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

Hartmann T, Overhagen S, Ouwens DM, Raschke S, Wohlfart P, Tennagels N, Wronkowitz N, Eckel J; Cardiovasc Diabetol. 2016 Jul 15;15:96. doi: 10.1186/s12933-016-0410-9


Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy

Hertz LD, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman LS, Watson D, Krens SD, Mulkey F, Renn CN, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ and McLeod HL; AACR Journals. 2016 May 3


Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M, Burgos JI, Vila-Petroff M, Dutra FF, Bozza M, Paiva CN, Carvalho AB, Bonomo A, Fleischmann BK, Campos de Carvalho AC and Medei E; Nat. Commun. 7, 13344 doi: 10.1038/ncomms13344. 2016 April 15


Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR; Stem Cells Transl Med. 2016 March 31


Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.

Gossmann M, Frotscher R, Linder P, Neumann S, Bayer R, Epple M, Staat M, Artmann AT, Artmann GM; Cell Physiol Biochem, 2016 Mar 17


Reduction in Na+ Current by Angiotensin II is Mediated by PKcα in Mouse and Human Induced Pluripotent Stem Cells Derived Cardiomyocytes

Mathieu S, El Khoury N, Rivard K, Gelinas R, Goyette P, Paradis P, Nemer M, Fiset C; Heart Rhythm Journal, 2016 Feb 24


Mechanisms of acquired long QT syndrome in patients with propionic acidemia

Bodi I, Grünert S, Becker N, Stölzle-Feix S, Spiekerkoetter U, Zehender M, Bugger H, Bode C, Odening KE;  Heart Rhythm Journal, 2016 Feb 05


Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy

Yvonne Aratyn-Schaus, Francesco S. Pasqualini, Hongyan Yuan, Megan L. McCain, George J.C. Ye, Sean P. Sheehy, Patrick H. Campbell, and Kevin Kit Parker; J Cell Biol. 2016 Feb 15;212(4):389-97


Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue

Ralf Frotscher, Danita Muanghong, Gözde Dursun, Matthias Goßmann, Ayşegül Temiz-Artmann, Manfred Staat; J Biomechanics. 2016 Feb 11;pii: S0021-9290(16)30115-4.


Tissue-Mimicking Geometrical Constraints Stimulate Tissue-Like Constitution and Activity of Mouse Neonatal and Human-Induced Pluripotent Stem Cell-Derived Cardiac Myocytes

Polarczyk G, Raulf A, Gunkel M, Fleischmann B K, Lemor Robert and Hausmann M; J. Funct. Biomater. 2016 Jan 7

 

2015


3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Palanker R, Glaubnitz M, Martens U, Medvedev N, von der Ehe M, Felix SB, Münzenberg M, Delcea M; Advanced Healthcare Materials, 2015 Dec 16


Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes

Kucera JP, Prudat Y, Marcu IC, Azzarito M, Ullrich ND; Front Cell Dev Biol. 2015; 3: 58


High throughput bioassay for beta1-adrenoceptor autoantibody detection

Shivanjali JB, Haberland A, Bartel S, Müller J, Choi T, Wallukat G; IJC Journal. 2015 Sept 15


Computational Investigation of Drug Action on Human-Induced Stem Cell-derived Cardiomyocytes

Ralf Frotscher, Jan-Peter Koch, Manfred Staat; ASME. J Biomech Eng 137(7), 071002, 2015 Jul 01


Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform

Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE; Biochim Biophys Acta. 2015 Oct 31


Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk

Obejero-Paz CA, Bruening-Wright A, Kramer J, Hawryluk P, Tatalovic M, Dittrich HC, Brown AM; Scientific Reports 2015 Nov 30;5:17623


CiPA: Ongoing testing, future qualification procedures, and pending issues

Cavero I, Holzgrefe H; J Pharmacol and Toxicol Methods 2015 Nov-Dec;76:27-37


New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings

Doerr L, Thomas U, Guinot DR, Bot CT, Stoelzle-Feix S, Beckler M, George M, Fertig N; J Lab Autom. 2015 Apr;20(2):175-88


A Non-invasive Platform for Functional Characterization of Stem-Cell- Derived Cardiomyocytes with Applications in Cardiotoxicity Testing

Maddah M, Heidmann JD, Mandegar MA, Walker CD, Bolouki S, Conklin BR, Loewke KE; Stem Cell Reports 2015 Apr 14;4(4):621-631


Functional Characterization and Comparison ofIntercellular Communication in StemCell-Derived Cardiomyocytes

Marcu IC, Illaste A, Heuking P, Jaconi ME, Ullrich ND; Stem Cell Express 2015 Apr 8, 2015;33:2208–2218


Novel screening techniques for ion channel targeting drugs

Obergrussberger A, Stölzle-Feix S, Becker N, Brüggemann A, Fertig N, Möller C; Channels (Austin). 2015 Nov 2;9(6):367-75


Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Müller M, Stiehler J, George M, Fertig N; J Lab Autom. 2015 Dec 23

 

2014


Action Potential Characterization of Human iPSC-derived Cardiomyocytes using Automated Patch-Clamp Technology

Scheel O, Frech S, Amuzescu B, Eisfeld J, Lin K, Knott T; Assay and Drug Development Technologies


L-Type Ca++ Channel Responses to Bay K 8644 in Stem Cell-Derived Cardiomyocytes Are Unusually Dependent on Holding Potential and Charge Carrier

Ji J, Kang J, Rampe D; Assay and Drug Development Technologies, Vol. 12, No. 6, July/August 2014


Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues

McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK; Biomaterials, Vol. 35, Issue 21, July 2014, 5462-5471


Quality Metrics for Stem Cell-Derived Cardiac Myocytes

Sheehy S, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK; Stem Cell Reports, Vol. 2, 282-294, 11 March 2014

 

2013


Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: Effects of reference compounds

Himmel HM; J PharmTox, 2013 Jul/Aug; 68: 97-111


Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system

Becker N, Stoelzle S, Goepel S, Guinot D, Mumm P Haarmann C, Malan D, Bohlen H, Kossolov E, Kettenhofen R, George M, Fertig N, Brueggemann A; J PharmTox, 2013 Jul/Aug; 68: 82-87.

 

2012


Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryopnic stem cells

Gabriel E, Schievenbusch S, Kolossov E, Hengstler JG, Rotsheyn T, Bohlen H, Nierhoff D, Hescheler J, Drobinskaya I, PLoS One. 2012;7(9):e44912. doi:10. 1371/journal.pone.0044912. Epub 2012 Sep 24


Dynamic monitoring of beating periodicity of stem cell derived cardiomyocytes as a predictive tool for preclinical safety assesment

Abassi YA, Xi B, Li N, Ouyang W, Seiler A, Matzele M, Kettenhofen R, Bohlen H, Ehlöich A, Kolossov E, Wang X, Xu X. Br J Pharmacol. 2012 Mar;165(5):1424-41

 

2011


State of the Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening

Stölzle S, Obergrussberger A, Brüggemann A, Haarmann C, George M, Kettenhofen R, Fertig N. Front Pharmacol. 2011;2:76. Epub 2011 Nov 24


MicroRNA profiling during cardiomyocyte specific differentiation of murine embryonic stem cells based on two different miRNAarray platforms

Gan L, Schwengberg S, Deneke B.PLoS One. 2011;6(10):e25809. Epub 2011 Oct 3


Automated patch clamp on mESC-derived cardiomyocytes for cardiotoxicity prediction

Stölzle S, Haythornwaite A, Kettenhofen R, Kolossov E, Hohlen H, George M, Brüggemann A, Fertig N. J Biomol Screen. 2011 Sep;16(8):910-6. Epub 2011 Jul 20


Cardiac Toxicity

Kettenhofen R, Schwengberg S, in: ADMET for Med icinal Chemists, Eds.: Tsaioun K, Kates SA

 

2010


Embryonic stem cells as a tool for drug screening and toxicity testing

Schwengberg S, in: Stem Cell Engineering, Eds.: Artmann GM, Minger S, Hescheler J. (Publication 1st ed April 2010, Springer)


Chemically induced cardiomyogenesis of mouse embryonic stem cells

Berkessel A, Seelig B, Schwengberg S, Hescheler J, Sachinidis A. Chembiochem. 2010 Jan 25;11(2):208-17


2009


A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop

Marx-Stoelting P, Adriaens E, Ahr HJ, Bremer S, Garthoff B, Gelbke HP, Piersma A, Pellizzer C, Reuter U, Rogiers V, Schenk B, Schwengberg S, Seiler A, Spielmann H, Steemans M, Stedman DB, Vanparys P, Vericat JA, Verwei M, van der Water F, Weimer M, Schwarz M. Altern Lab Anim. 2009 Jul;37(3):313-28; link


Response to "The microEST in vitro test for embryotoxicity - a case of mistaken identity?" by Robert Combes

Schwengberg S, Bohlen H, Fronhoff B. Toxicol In Vitro. 2009 Mar;23(2):362-3. Epub 2008 Dec 10; link

 

2008


Pre-clinical assessment of cardiac toxicity

Kettenhofen R, Bohlen H; Drug Discovery Today 2008 Aug:13(15-16):702-7. Epub 2008 Jul 24; link


Scalable selection of Hepatocyte- and Hepatocyte precursor-like cells from transgenic murine ES cells

Dobrinskaya I, Linn T, Saric T, Bretzel RG, Bohlen H, Hescheler J, Kolossov E; Stem Cells 2008 Sep;26(9):2245-56. Epub 2008 Jun 12; link


Genetic modification of cells for transplantation

Lai Y, Dobrinskava I, Kolossov E, Chen C, Linn T; Adv Drug Deliv Rev. 2008 Jan 14:60(2):146-59. Epub 2007 Oct 18. Review; link

 

2007


Potential risks of bone marrow cell transplantation into infarcted hearts

Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM, Fries JW, Tiemann K, Bohlen H, Hescheler J, Welz A, Bloch W, Jacobsen SE, Fleischmann BK. Blood. 2007 Aug 15;110(4):1362-9. Epub 2007 May 4

 

2006


Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

Kolossov E, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren JM, Sasse P, Rubenchik O, Fries JW, Wenzel D, Geisen C, Xia Y, Lu Z, Duan Y, Kettenhofen R, Jovinge S, Bloch W, Bohlen H, Welz A, Hescheler J, Jacobsen SE, Fleischmann BK. J Exp Med. 2006 Oct 2;203(10):2315-27 . Epub 2006 Sep 5


Antibody repertoires generated by VH replacement and direct VH to JH joining

Koralov SB, Novobrantseva TI, Konigsmann J, Ehlich A, Rajewsky K. Immunity. 2006 Jul;25(1):43-53


Identification of Small Signalling Molecules Promoting Cardiac-Specific Differentiation of Mouse Embryonic Stem Cells

Sachinidis A, Schwengberg S, Hippler-Altenburg R, Mariappan D, Kamisetti N, Seelig B, Berkessel A, Hescheler J. Cell Physiol Biochem 2006;18:303-314


2005


Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes

Kolossov E, Lu Z, Drobinskaya I, Gassanov N, Duan Y, Sauer H, Manzke O, Bloch W, Bohlen H, Hescheler J, Fleischmann BK. FASEB J. 2005 Apr;19(6):577-9. Epub 2005 Jan 19


In vitro embryotoxicity assessment with dental restorative materials

Schwengberg S, Bohlen H, Kleinsasser N, Kehe K, Seiss M, Walther UI, Hickel R, Reichl FX. J Dent. 2005 Jan;33(1):49-55


Phase I/II combined chemoimmunotherapy with carcinoembryonic antigen-derived HLA-A2-restricted CAP-1 peptide and irinotecan, 5-fluorouracil, and leucovorin in patients with primary metastatic colorectal cancer

Weihrauch MR, Ansen S, Jurkiewicz E, Geisen C, Xia Z, Anderson KS, Gracien E, Schmidt M, Wittig B, Diehl V, Wolf J, Bohlen H, Nadler LM. Clin Cancer Res. 2005 Aug 15;11(16):5993-6001


Elevated serum levels of CC thymus and activation-related chemokine (TARC) in primary Hodgkin's disease: potential for a prognostic factor

Weihrauch MR, Manzke O, Beyer M, Haverkamp H, Diehl V, Bohlen H, Wolf J, Schultze JL. Cancer Res. 2005 Jul 1;65(13):5516-9


2004


Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development

Fleischmann BK, Duan Y, Fan Y, Schoneberg T, Ehlich A, Lenka N, Viatchenko-Karpinski S, Pott L, Hescheler J, Fakler B. J Clin Invest. 2004 Oct;114(7):994-1001


Determination of electrical properties of ES cell-derived cardiomyocytes using MEAs

Hescheler J, Halbach M, Egert U, Lu ZJ, Bohlen H, Fleischmann BK, Reppel M. J Electrocardiol. 2004;37 Suppl:110-6. Review


Implication of therapeutic cloning for organ transplantation

Hescheler J, Wartenberg M, Wenzel D, Roell BK, Lu Z, Xia Y, Donmez F, Ling FC, Acker H, Kolossov E, Kazemi S, Sasse P, Raible A, Bohlen H, Bloch W, Sauer H, Welz A, Fleischmann BK. Eur J Cardiothorac Surg. 2004 Dec;26 Suppl 1:S54-5; discussion S55-6


Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation

Spitkovsky D, Sasse P, Kolossov E, Bottinger C, Fleischmann BK, Hescheler J, Wiesner RJ. FASEB J. 2004 Aug;18(11):1300-2. Epub 2004 Jun 4


2003


Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke

Erdo F, Buhrle C, Blunk J, Hoehn M, Xia Y, Fleischmann B, Focking M, Kustermann E, Kolossov E, Hescheler J, Hossmann KA, Trapp T. J Cereb Blood Flow Metab. 2003 Jul;23(7):780-5


Cardiac specific differentiation of mouse embryonic stem cells

Sachinidis A, Fleischmann BK, Kolossov E, Wartenberg M, Sauer H, Hescheler J. Cardiovasc Res. 2003 May 1;58(2):278-91


2002


Differential role of bFGF and VEGF for vasculogenesis

Kazemi S, Wenzel D, Kolossov E, Lenka N, Raible A, Sasse P, Hescheler J, Addicks K, Fleischmann BK, Bloch W. Cell Physiol Biochem. 2002;12(2-3):55-62


Cellular cardiomyoplasty in a transgenic mouse model

Roell W, Fan Y, Xia Y, Stoecker E, Sasse P, Kolossov E, Bloch W, Metzner H, Schmitz C, Addicks K, Hescheler J, Welz A, Fleischmann BK. Transplantation. 2002 Feb 15;73(3):462-5


Cellular cardiomyoplasty improves survival after myocardial injury

Roell W, Lu ZJ, Bloch W, Siedner S, Tiemann K, Xia Y, Stoecker E, Fleischmann M, Bohlen H, Stehle R, Kolossov E, Brem G, Addicks K, Pfitzer G, Welz A, Hescheler J, Fleischmann BK. Circulation. 2002 May 21;105(20):2435-4

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