CardioEffect Screening Service

Cells Cor.4U@ human iPS-derived cardiomyocytes
Species Human (mouse possible, please inquire)
Reporter none
Service Content     Investigation of a compound's effect on spontaneous beating (frequency, amplitude, rhythmicity) of Cor.4U cardiomyocytes using ACEA's xCELLigence RTCA Cardio instrument
Delivery A study protocol will be sent to initiate the study. Results are sent as draft and final study report.
Timelines Experiment time: 2 weeks per compound.
Draft report: within 4 weeks
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Cor.4U® human iPS cell-derived cardiomyocytes in combination with the xCELLigence RTCA Cardio instrument provide a standardized, homogenous and reproducible assay system for the in vitro detection of a compound‘s potential to influence cardiomyocyte function. Results obtained in the study will indicate a potential effect on cardiac beating, e.g. changes of beating frequency, spike amplitude, induction of arrhythmia, or beating arrest.

Axiogenesis' stem cell-derived cardiomyocytes provide a physiologically relevant and predictive in vitro model for cardiac safety screening in early lead optimization. Results obtained in our electrophysiology assays can be compared directly with results obtained in our cellular toxicity assays. This improves the ability to determine potential cardiotoxic effects of compounds in early stages of drug development, providing better measures to move lead compounds towards pre-clinical and clinical development.

The CardioEffect Screening has been validated in house using 24 drugs with known cardiac safety profile. Reference compounds are included on each assay plate to ensure reproducible results.

Fig. 1: Application of different concentrations of E-4031 (Cor.4U@ xCELLigence assay)

Advantages of CardioEffect Screening Service

  • Integrated cell culture model representing primary-like cardiac physiology.
  • Predictive, relevant and robust assay system.
  • Assessement of both acute and long-term effects on cardiomyocyte function (beating) and overall health
  • Combination with other read-outs of cell viability and cytotoxicity possible.
  • Early and quick results on a compound's safety profile, time- and cost effective.

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